Chih-Hao Lee, Ph.D.
Name Chih-Hao Lee, Ph.D.
Incumbent Distinguished Professor
所屬單位 Director

Immunometabolism, adaptive metabolic responses, adipose tissue and resident immune cells, glucose and fatty acid metabolism, , metabolomics, metabolic diseases, neuroinflammation

Ph.D., University of Minnesota,USA, 1999
B.S., Chemical Engineering, National Tsing-Hua University, Taiwan, 1989
NCLscan:
  •  clee2023@as.edu.tw
研究方向/領域

RESEARCH INTERESTS

The main research interest of the lab is to understand bioenergetic controls of physiological processes that impact metabolic health. Approaches employed include a variety of tools in molecular/cell biology, biochemistry, single cell RNAseq, and metabolomics as well as mouse models of obesity and related metabolic diseases. Current projects, with an emphasis on the crosstalk between metabolic and immune signaling, focus on the following areas:

  • Mechanisms of metabolic adaptation to physiological stress, such as endurance exercise, cold exposure and feeding/fasting.
  • Adipose tissue resident immune cell dynamics in normal and pathological conditions.
  • Mitochondrial bioenergetics in microglial cell-mediated neuroinflammation.
  • Multi-omics approaches (e.g., sc/snRNA, ATACseq, ChIPseq, proteomics and metabolomics) to understand fat cell biology.
Dr
EDUCATION AND POSITIONS HELD
  • 2023-present Director, Genomics Research Center, Academia Sinica
  • 2023-present Distinguished Professor, Genomics Research Center, Academia Sinica
  • 2015-2023 Professor, Harvard School of Public Health
  • 2010-2015 Associate Professor, Harvard School of Public Health
  • 2004-2010 Assistant Professor, Harvard School of Public Health
  • 1999-2004 Postdoctoral fellow, Salk Institute
HONORS
  • 2012 Armen H. Tashjian Jr. Award for Excellence in Endocrine Research
  • 2011 The Mentoring Award by the HSPH graduating class of 2011
  • 2006 Scientist Development Grant awarded by the American Heart Association
  • 2005 The William F. Milton Fund Award
  • 1998 Bacaner Research Award, presented by Minnesota Medical Foundation for excellence in creative research
1. Immune-metabolic signaling crosstalk in tissue homeostasis
 
a. Kang K, Reilly SM, Karabacak V, Gangl MR, Fitzgerald K, Hatano B, Lee CH. Adipocyte-derived Th2 cytokines and myeloid PPAR delta regulate macrophage polarization and insulin sensitivity. Cell Metab. 2008; 7:485-495.  PMID: 18522830. PMCID: PMC2586840
b. Bhargava P, Li C, Stanya KJ, Jacobi D, Liu S, Dai L, Liu S, Gangl MR, Harn DA, Lee CH. Immunomodulatory glycan LNFPIII alleviates hepatosteatosis and insulin resistance through direct and indirect control of metabolic pathways. Nat Med. 2012; 18:1665-1672. PMID: 23104131. PMCID: PMC3493877
c. Stanya KJ, Jacobi D, Liu S, Bhargava P, Dai L, Gangl MR, Inouye K, Barlow JL, Ji Y, Mizgerd JP, Qi L, Shi H, McKenzie, Lee CH. Direct control of hepatic glucose production by Il-13. J Clin Invest 2013; 123:261-271. PMID: 23257358. PMCID: PMC3533296
d. Knudsen NH, Stanya KJ, Hyde AL, Chalom MM, Alexander RK, Liou YH, Gangl MR, Jacobi D, Liu S, Sopariwala DH, Fonseca-Pereira D, Li J, Hu FB, Garrett WS, Narkar V, Ortlund EA, Kim JH, Paton CM, Cooper JA, Lee CH. Interleukin 13 drives metabolic conditioning of muscle to endurance exercise. Science 2020; 368: eaat3987. PMID: 32355002.
 
2. Energy metabolism and mitochondrial function in the liver-muscle axis
 
a. Liu S, Brown JD, Stanya KJ, Homan E, Leidl M, Inouye K, Bhargava P, Gangl MR, Dai L, Hatano B, Hotamisligil GS, Saghatelian A, Plutzky J, Lee CH. A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid utilization. Nature 2013; 502:550-553. PMID: 24153306. PMCID: PMC4141623
b. Jacobi D, Liu S, Burkewitz K, Kory N, Knudsen NH, Alexander RK, Unluturk U, Li X, Kong X, Hyde AL, Gangl MR, Mair WB, Lee CH. Hepatic Bmal1 regulates rhythmic mitochondrial dynamics and promotes metabolic fitness. Cell Metab 2015; 22:709-720. PMID: 26365180; PMCID: PMC4598294.
c. Liou YH, Personnaz J, Jacobi D, Knudsen NH, Chalom MM, Starost KA, Nnah IC, Lee CH. Hepatic Fis1 regulates mitochondrial integrated stress response and improves metabolic homeostasis. JCI Insight 2022; 7: e150041. PMID: 35015731.
 
3. Transcriptional regulation of metabolic and inflammatory processes
 
a. Reilly SM, Bhargava P, Liu S, Gangl MR, Gorgun C, Nofsinger RR, Evans RM, Qi L, Hu FB, Lee CH. Nuclear receptor co-repressor SMRT regulates mitochondrial oxidative metabolism and mediates aging related metabolic deterioration. 2010. Cell Metab, 2010; 12:643-653. PMID: 21109196. PMCID: PMC3033658
b. Dai L, Bhargava P, Stanya KJ, Alexander RK, Liou Y-H, Jacobi D, Knudsen NH, Hyde A, Gangl MR, Liu S, Lee CH. Macrophage alternative activation confers protection against lipotoxicity-induced cell death. Mol Metab 2017, 6:1186. PMID: 29031719. PMCID: PMC5641682.
c. Alexander RK, Liou YH, Knudsen NH, Starost KA, Xu C, Hyde AL, Liu SL, Jacobi D, Liao NS Lee CH. Bmal1 integrates mitochondrial metabolism and macrophage activation.  eLife 2020; 9: e54090. PMID: 32396064.
  主任-2_2