Wen-Bin Yang, Ph.D.
Name Wen-Bin Yang, Ph.D.
現任 Senior Research Specialist/Scientist
所屬單位 Purified and characterized the monosaccharide composition and chemical structure of polysaccharides. Developed an o-phenylenediamine fluorescent label for analysis and process quality control of glycosylated drugs.

Ph.D., Department of Chemistry, National Taiwan University, 1994–1998
M. S., Department of Chemistry, National Chung Hsing University, 1992–1994
B. S., in Chemistry, ChungYuanChristianUniversity, Taiwan R.O.C., 1989–1992
 
名片
專長

FACILITY MANAGEMENT / EXPERTISE:

Research Experience
Managed a molecular drug library and operated key analytical instruments including capillary electrophoresis and liquid-liquid extraction systems.

Technical Expertise
Specialized in the application of organic chemistry to the extraction, purification, synthesis, and analysis of highly polar natural compounds. Developed methods for the degradation of high molecular weight polysaccharides using chemical and enzymatic approaches, followed by purification and characterization of their monosaccharide composition, stereochemistry, chemical structure, and molecular size. Investigated glycans and glycan complexes associated with disease. Developed o-phenylenediamine-based fluorescent labeling reagents and applied this platform to the analysis and process quality control of foods, dietary supplements, and glycosylated pharmaceuticals. Proficient in conventional glycan composition and structural analysis techniques, including HPAEC-PAD, NMR, LC-MS, MALDI-TOF-MS, and GC-MS.

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EDUCATION AND POSITIONS HELD
  • 2018-present Senior Research Specialist, Genomics Research Center, Academia Sinica
  • 2013-2018 Associate Research Specialist, Genomics Research Center, Academia Sinica, Taiwan
  • 2003-2013 Assistant Research Fellow, GenomicsResearchCenter, Academia Sinica
  • 2002-2003 Assistant Professor, Graduate Institute of Pharmacognosy Science, Taipei Medical University
  • 1998-2002 Postdoctoral Research Fellow, Institute of Biological Chemistry, Academia Sinica
HONORS
  • 2000 and 2013 The best research paper in Journal of the Chinese Chemical Society
  • 1998-2002 AS postdoctoral fellowship in IBC of Academia Sinica
  • 1994-1998 Graduate Fellowship of National Science Council (NSC)
  • 1992-1994 Fellowship of Ministry of Education and NSC
  • S.-M. Liang, Y.-P. Chen, W.-B. Yang, C.-H. Wong, accepted, “Reishi F3 subfraction polysaccharides and methods of using same”, Patent Application, pp. US 2009/0263897 A1.
  • M. H. Wu, Y. C. Lee, W. J. Tsai, W. B. Yang, Y. C. Chen, K. A. Chuang, J. F. Liao, C. C. Wang, Y. C. Kuo, 2010, “Characterized polysaccharides from black soybean induce granulocyte colony-stimulated factor gene expression in a phosphoinositide 3-kinase-dependent manner”, IMMUNOLOGICAL INVESTIGATIONS, 39, 1-23. (SCIE)
  • C. Y. Lai, J. T. Hung, H. H. Lin, A. L. Yu, S. H. Chen, Y. C. Tsai, L. E. Shao, W. B. Yang, J. Yu, 2010, “Immunomodulatory and adjuvant activities of a polysaccharide extract of Ganoderma lucidum in vivo and in vitro”, VACCINE, 28(31),4945-4954. (SCIE)
  • C. Lin, W. T. Hung, C. Y. Kuo, K. S. Liao, Y. C. Liu, W. B. Yang, 2010, “Iodine-catalyzed oxidative condensation of aldoses with diamine on aldo-naphthimidazoles synthesis for carbohydrate analysis”, MOLECULES, 15(3), 1340-1353. (SCIE)
  • C. C. Chang, A. F. Ku, Y. Y. Tseng, W. B. Yang, J. M. Fang, C. H. Wong, 2010, “6,8-Di-C-glycosyl flavonoids from Dendrobium huoshanense”, JOURNAL OF NATURAL PRODUCTS, 73(2), 229-232. (SCIE)
  • T. L. Hsu, S. C. Cheng, W. B. Yang, S. W. Chin, B. H. Chen, M. T. Huang, S. L. Hsieh, C. H. Wong, 2009, “Profiling carbohydrate-receptor interaction with recombinant innate immunity receptor-Fc fusion proteins”, JOURNAL OF BIOLOGICAL CHEMISTRY, 284(50), 34479-34489. (SCIE)
  • Yves. S. Y. Hsieh, S. F. Liao, W. B. Yang, 2009, “Biologically active polysaccharides in medicinal plants”, NEW ZEALAND JOURNAL OF FORESTRY SCIENCE, 39, 217-223. (SCIE)
  • M.H. Chuang , S.H. Chiou, C.H. Huang, W.B. Yang, C.H. Wong, 2009, “The lifespan-promoting effect of acetic acid and Reishi polysaccharide”, BIOORGANIC & MEDICINAL CHEMISTRY, 17(22), 7831-7841. (SCIE)
  • Y. T. Huang, S. Y. Lyu, P. H. Chuang, N. S. Hsu, Y. S. Li, H. C. Chan, Y. C. Liu, C. J. Wu, W. B. Yang, T. L. Li, 2009, “In vitro characterization of enzymes involved in the synthesis of nonproteinogenic residue (2S,3S)-beta-methylphenylalanine in glycopeptide antibiotic mannopeptimycin”, CHEMBIOCHEM, 10(15), 2480-2487. (SCIE)
  • C.-H. Wong, M.-H. Chuang, W.-B. Yang, S.-H. Chiou, 2009, “Longevity-Promoting Effects of Acetic Acid and Reishi Polysaccharide”, PCT Patent Application, pp. No. PCT/US09/40879.
  • C.-H. Wong, M.-H. Chuang, W.-B. Yang, S.-H. Chiou, 2009, “Longevity-Promoting Effects of Acetic Acid and Reishi Polysaccharide”, US Patent Application, pp. No. 12/425,319.
  •  C.-H. Wong, J.-M. Fang, W.-B. Yang, T.-J. R. Cheng, Y. S.-Y. Hsieh, C. Chien, C.-C. Lin, H.-Y. Wen, 2009, “Structure and Bioactivity of the Polysaccharides in Medicinal Plant Dendrobium huoshanense”, PCT Patent Application, pp. No. PCT/US2009/033940.
  •  C.-H. Wong, J.-M. Fang, W.-B. Yang, T.-J. R. Cheng, Y. S.-Y. Hsieh, C. Chien, C.-C. Lin, H.-Y. Wen, 2009, “Structure and Bioactivity of the Polysaccharides in Medicinal Plant Dendrobium huoshanense”, Taiwan Patent Application, pp. No. 098104560.
  •  C.-H. Wong, J.-M. Fang, W.-B. Yang, T.-J. R. Cheng, Y. S.-Y. Hsieh, C. Chien, C.-C. Lin, H.-Y. Wen, 2009, “Structure and Bioactivity of the Polysaccharides in Medicinal Plant Dendrobium huoshanense”, US Patent Application, pp. No. 12/378,263.
  • Shao, Y. M.; Yang, W. B.; Kuo, T. H.; Tsai, K. C.; Lin, C. H.; Yang, A. S.; Liang, P. H.; Wong, C. H., 2008, “Design, Synthesis, and Evaluation of Trifluoromethyl Ketones as Inhibitors of SARS-CoV 3CL Protease”, Bioorganic & Medicinal Chemistry, 16, 4652-4660. (SCIE)
  • M. L. Chen, A. K. Adak, N. C. Yeh, W. B. Yang, Y. J. Chuang, C. H. Wong, K. C. Hwang, J. R. Hwu, S. L. Hsieh, C. C. Lin, 2008, “Fabrication of an oriented Fc-fused lectin microarray through boronate formation”, Angewandte Chemie-International Edition, 47, 8627-8630. (SCIE)
  • Y. S. Hsieh, C. Chien, S. K. Liao, S. F. Liao, W. T. Hung, W. B. Yang, C. C. Lin, T. J. Cheng, C. C. Chang, J. M. Fang and C. H. Wong, 2008, “Structure and bioactivity of the polysaccharides in medicinal plant Dendrobium huoshanense”, Bioorganic & Medicinal Chemistry, 16, 6054-6068. (SCIE)
  • W. T. Hung.; S. H. Wang.; C. H. Chen.; W. B. Yang, 2008, “Structure determination of beta-glucans from Ganoderma lucidum with matrix-assisted laser desorption/ionization (MALDI) mass spectrometry”, Molecules, 13, 1538-1550. (SCIE)
  • C. Lin, P. T. Lai, K. S. Liao, W. T. Hung, W. B. Yang and J. M. Fang, 2008, “Using molecular iodine in direct oxidative condensation of aldoses with diamines: An improved synthesis of aldo-benzimidazoles and aldo-naphthimidazoles for carbohydrate analysis”, J. Org. Chem, 73, 3848-3853. (SCIE)
  • K. F. Hua, H. Y. Hsu, L. K. Chao, S. T. Chen, W. B. Yang, J. Hsu and C. H. Wong, 2007, “Ganoderma lucidum Polysaccharides Enhance CD14 Endocytosis of LPS and Promote TLR4 Signal Transduction of Cytokine Expression”, Journal of Cellular Physiology, 212, 537-550. (SCIE)
  • K. C. Cheng, H. C. Huang, J. H. Chen, J. W. Hsu, H. C. Cheng, C. H. Ou1, W. B. Yang, S. T. Chen, C. H. Wong and H. F. Juan, 2007, “Ganoderma lucidum polysaccharides in human monocytic leukemia cells: from gene expression to network construction”, BMC Genomics, 8, 411. (SCIE)
  • W. C. Chang, L. C. L. Huang, Y. S. Wang, W. P. Peng, H. C. Chang, N. Y. Hsu, W. B. Yang and C. H. Chen, 2007, “Matrix-assisted laser desorption/ionization (MALDI) mechanism revisited”, Analytica Chimica Acta, 582(1), 1-9. (SCIE)
  • N. Y. Hsu, W. B. Yang, C. H. Wong, Y. C. Lee, R. T. Lee, Y. S. Wang and C. H. Chen, 2007, “Matrix-assisted laser desorption/ionization mass spectrometry of polysaccharides with 2',4',6'-trihydroxyacetophenone as matrix”, Rapid Communications in Mass Spectrometry, 21, 2137-2146. (SCIE)
  •  C.-H. Wong, H.-Y. Hsu, K.-F. Hua, C.-H. Lin, J. Hsu, S.-T. Chen, K.-I. Lin, W.-B. Yang, J. Yu, A. Yu, 2007, “Methods and compositions associated with administration of an extract of Ganoderma lucidum”, European Patent Application, pp. No. 05810080.1.
  •  C.-H. Wong, H.-Y. Hsu, K.-F. Hua, C.-H. Lin, J. Hsu, S.-T. Chen, K.-I. Lin, W.-B. Yang, J. Yu, A. Yu, 2007, “Methods and compositions associated with administration of an extract of Ganoderma lucidum”, Japanese patent application, pp. No. 2007536927.
  • Y. M. Shao, W. B. Yang, H. P. Peng, M. F. Hsu, K. C. Tsai, T. H. Kuo, A. S. Yang, A. H. J. Wang, P. H. Liang, C. H. Lin and C. H. Wong, 2007, “Structure-Based Design and Synthesis of Highly Potent SARS-CoV 3CL Protease Inhibitors”, ChemBioChem, 8(14), 1654-1657. (SCIE)
  • H. J. Huang and W. B. Yang, 2007, “Synthesis of moenocinol and its analogs using BT-sulfone in Julia-Kocienski olefination”, Tetrahedron Lett, 48, 1429-1433. (SCIE)