Tsui-Ling Hsu, Ph.D.
Name Tsui-Ling Hsu, Ph.D.
現任 Associate Research Specialist/Scientist
所屬單位
Glycoscience Core Facility

Ph.D., Microbiology and Immunology, National Yang-Ming University, Taiwan, 2004
 
名片
專長

FACILITY MANAGEMENT / EXPERTISE:

Responsible for managing the Glycoscience Core Facility and providing technical support, with a focus on integrating relevant research resources within Academia Sinica. Offers one-stop services for glycan analysis and research consultation. Experienced in mass spectrometry, high-performance liquid chromatography (HPLC), glycan arrays, plant lectin arrays, and human lectin platforms, including C-type lectins and galectins, to support diverse research needs in glycoscience.

From research consultation and sample processing to data analysis and scientific recommendations, dedicated to building strong connections between researchers and the platform. Actively promotes interdisciplinary collaboration and knowledge exchange, with the goal of advancing the application and development of glycoscience research.

AS Glycoscience 海報_2024
EDUCATION AND POSITIONS HELD
  • 2018-present Associate Research Scientist, Genomics Research Center, Academia Sinica
  • 2014-2018 Assistant Research Scientist, Genomics Research Center, Academia Sinica
  • 2007-2014 Postdoctoral Fellow, Genomics Research Center, Academia Sinica
  • 2005-2007 Research Associate, Department of Chemistry, The Scripps Research Institute, USA
HONORS
  • 2013 Outstanding Performance Awards in Genomics Research Center, Academia Sinica
  • 2005-2007 Taiwan Merit Scholarships
  • Chen Nai-Yu, Lin Chih-Wei, Lai Ting-Yen, Wu Chung-Yi, Liao Pei-Chi, Hsu Tsui-Ling, Wong Chi-Huey, 2024, “Increased expression of SSEA-4 on TKI-resistant non–small cell lung cancer with EGFR-T790M mutation”, Proceedings of the National Academy of Sciences, 121(5), e2313397121-e2313397121.
  • Huang Han-Wen, Chen Chen-Chun, Lin Kuo-I, Hsu Tsui-Ling, Wong Chi-Huey, 2024, “Single Site <i>N</i>-Glycosylation of B Cell Maturation Antigen (BCMA) Inhibits γ-Secretase-Mediated Shedding and Improves Surface Retention and Cell Survival”, ACS Chemical Biology, 19(1), 153-161. (SCIE)
  • Chen WA, Chen YH, Hsieh CY, Hung PF, Chen CW, Chen CH, Lin JL, Cheng TR, Hsu TL, Wu YT, Shen CN, Cheng WC, 2022, “Harnessing natural-product-inspired combinatorial chemistry and computation-guided synthesis to develop N-glycan modulators as anticancer agents.”, Chemical science, 13(21), 6233-6243. (SCIE)
  • Lee RH, Wang YJ, Lai TY, Hsu TL, Chuang PK, Wu HC, Wong CH, 2021, “Combined Effect of Anti-SSEA4 and Anti-Globo H Antibodies on Breast Cancer Cells.”, ACS chemical biology, 16(8), 1526-1537. (SCIE)
  • Jiang Min-Chao, Hu Chung-Chi, Hsu Wei-Li, Hsu Tsui-Ling, Lin Na-Sheng, Hsu Yau-Heiu, 2020, “Fusion of a Novel Native Signal Peptide Enhanced the Secretion and Solubility of Bioactive Human Interferon Gamma Glycoproteins in Nicotiana benthamiana Using the Bamboo Mosaic Virus-Based Expression System”, Frontiers in Plant Science, 11, 594758. (SCIE)
  • Ming-Hsuan Lee, Tsui-Ling Hsu, Jinn-Jy Lin , Yu-Ju Lin, Yi-Ying Kao, Jui-Jen Chang, and Wen-Hsiung Li*, 2020, “Constructing a human complex type N-linked glycosylation pathway in Kluyveromyces marxianus”, PLOS ONE, 15(5), e0233492. (SCIE)
  • Pawar Sujeet, Hsu Li, Narendar Reddy Thatikonda, Ravinder Mettu, Ren Chien-Tai, Lin Yu-Wei, Cheng Yang-Yu, Lin Tzu-Wen, Hsu Tsui-Ling, Wang Sheng-Kai, Wong Chi-Huey, Wu Chung-Yi, 2020, “Synthesis of Asymmetric N-Glycans as Common Core Substrates for Structural Diversification through Selective Enzymatic Glycosylation”, ACS Chemical Biology, 15(9), 2382-2394. (SCIE)
  • Chuang Po-Kai, Hsiao Michael, Hsu Tsui-Ling, Chang Chuan-Fa, Wu Chung-Yi, Chen Bo-Rui, Huang Han-Wen, Liao Kuo-Shiang, Chen Chen-Chun, Chen Chi-Long, Yang Shun-Min, Kuo Chiung Wen, Chen Peilin, Chiu Ping-Tzu, Chen I-Ju, Lai Jiann-Shiun, Yu Cheng-Der Tony, Wong Chi-Huey, 2019, “Signaling pathway of globo-series glycosphingolipids and β1,3-galactosyltransferase V (β3GalT5) in breast cancer”, Proceedings of the National Academy of Sciences of the United States of America, 116(9),3518-3523. (SCIE)
  • Lo PW, Shie JJ, Chen CH, Wu CY, Hsu TL, Wong CH, 2018, “O-GlcNAcylation regulates the stability and enzymatic activity of the histone methyltransferase EZH2.”, Proceedings of the National Academy of Sciences of the United States of America, 115(28), 7302-7307. (SCIE)
  • Huang Yen-Wen, Yang Hwai-I, Wu Ying-Ta, Hsu Tsui-Ling, Lin Tzu-Wen, Kelly Jeffery W., Wong Chi-Huey, 2017, “Residues Comprising the Enhanced Aromatic Sequon Influence Protein N-Glycosylation Efficiency”, Journal of the American Chemical Society, 139(37), 12947-12955. (SCIE)
  • Tseng Tzu-Hao, Lin Tzu-Wen, Chen Chien-Yu, Chen Chein-Hung, Lin Jung-Lee, Hsu Tsui-Ling, Wong Chi-Huey, 2017, “Substrate Preference and Interplay of Fucosyltransferase 8 and N-Acetylglucosaminyltransferases”, Journal of the American Chemical Society, 139(28), 9431-9434. (SCIE)
  • Tsai Tsung-I, Li Shiou-Ting, Liu Chiu-Ping, Chen Karen Y., Shivatare Sachin S., Lin Chin-Wei, Liao Shih-Fen, Lin Chih-Wei, Hsu Tsui-Ling, Wu Ying-Ta, Tsai Ming-Hung, Lai Meng-Yu, Lin Nan-Horng, Wu Chung-Yi, Wong Chi-Huey, 2016, “An Effective Bacterial Fucosidase for Glycoprotein Remodeling”, ACS Chemical Biology, 12(1), 63-72. (SCIE)
  • Yeh Shih-Chi, Wang Pao-Yuan, Lou Yi-Wei, Khoo Kay-Hooi, Hsiao Michael, Hsu Tsui-Ling, Wong Chi-Huey, 2016, “Glycolipid GD3 and GD3 synthase are key drivers for glioblastoma stem cells and tumorigenicity”, Proceedings of the National Academy of Sciences, 113(20), 5592-5597.
  • Yen Hsin-Yung, Liu Ying-Chih, Chen Nai-Yu, Tsai Chia-Feng, Wang Yi-Ting, Chen Yu-Ju, Hsu Tsui-Ling, Yang Pan-Chyr, Wong Chi-Huey, 2015, “Effect of sialylation on EGFR phosphorylation and resistance to tyrosine kinase inhibition”, Proceedings of the National Academy of Sciences, 112(22), 6955-6960.
  • Lin TW, Chang HT, Chen CH, Chen CH, Lin SW, Hsu TL, Wong CH, 2015, “Galectin-3 binding protein and galactin-1 interaction in breast cancer cell aggregation and metastasis.”, Journal of the American Chemical Society, 137(30), 9685-9693. (SCIE)
  • Chen JT, Chen CH, Ku KL, Hsiao M, Chiang CP, Hsu TL, Chen MH, Wong CH, 2015, “Glycoprotein B7-H3 overexpression and aberrant glycosylation in oral cancer and immune response.”, Proceedings of the National Academy of Sciences of the United States of America, 112(42), 13057-62. (SCIE)
  • Cheung Sarah K. C., Chuang Po-Kai, Huang Han-Wen, Hwang-Verslues Wendy W., Cho Candy Hsin-Hua, Yang Wen-Bin, Shen Chia-Ning, Hsiao Michael, Hsu Tsui-Ling, Chang Chuan-Fa, Wong Chi-Huey, 2015, “Stage-specific embryonic antigen-3 (SSEA-3) and β3GalT5 are cancer specific and significant markers for breast cancer stem cells”, Proceedings of the National Academy of Sciences, 113(4), 960-965.
  • Chen PC, Chuang PK, Chen CH, Chan YT, Chen JR, Lin SW, Ma C, Hsu TL, Wong CH, 2014, “Role of N-Linked Glycans in the Interactions of Recombinant HCV Envelope Glycoproteins with Cellular Receptors.”, ACS chemical biology, 9(7), 1437-1443. (SCIE)
  • Lou YW, Wang PY, Yeh SC, Chuang PK, Li ST, Wu CY, Khoo KH, Hsiao M, Hsu TL, Wong CH, 2014, “Stage-specific embryonic antigen-4 as a potential therapeutic target in glioblastoma multiforme and other cancers.”, Proceedings of the National Academy of Sciences of the United States of America, 111(7), 2482-2487. (SCIE)
  • Chen CY, Jan YH, Juan YH, Yang CJ, Huang MS, Yu CJ, Yang PC, Hsiao M, Hsu TL, Wong CH, 2013, “Fucosyltransferase 8 as a functional regulator of nonsmall cell lung cancer.”, Proceedings of the National Academy of Sciences of the United States of America, 110(2), 630-635. (SCIE)
  • Hsu TL, Lin G, Koizumi A, Brehm K, Hada N, Chuang PK, Wong CH, Hsieh SL, Diaz A, 2013, “The surface carbohydrates of the Echinococcus granulosus larva interact selectively with the rodent Kupffer cell receptor.”, Molecular and biochemical parasitology, 192(1-2), 55-59. (SCIE)
  • Liu YC, Yen HY, Chen CY, Chen CH, Cheng PF, Juan YH, Chen CH, Khoo KH, Yu CJ, Yang PC, Hsu TL, Wong CH, 2011, “Sialylation and fucosylation of epidermal growth factor receptor suppress its dimerization and activation in lung cancer cells.”, Proceedings of the National Academy of Sciences of the United States of America, 108(28), 11332-11337. (SCIE)
  • Lee RT, Hsu TL, Huang SK, Hsieh SL, Wong CH, Lee YC, 2011, “Survey of immune-related, mannose/fucose-binding C-type lectin receptors reveals widely divergent sugar-binding specificities.”, Glycobiology, 21(4), 512-520. (SCIE)
  • Tsai CS, Liu PY, Yen HY, Hsu TL, Wong CH, 2010, “Development of trifunctional probes for glycoproteomic analysis.”, Chemical communications, 46(30), 5575-5577. (SCIE)
  • Hsu TL, Cheng SC, Yang WB, Chin SW, Chen BH, Huang MT, Hsieh SL, Wong CH, 2009, “Profiling carbohydrate-receptor interaction with recombinant innate immunity receptor-Fc fusion proteins.”, The Journal of biological chemistry, 284(50), 34479-34489. (SCIE)
  • Hsu TL, Hanson SR, Kishikawa K, Wang SK, Sawa M, Wong CH, 2007, “Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells.”, Proceedings of the National Academy of Sciences of the United States of America, 104(8), 2614-2619. (SCIE)
  • Hanson SR, Hsu TL, Weerapana E, Kishikawa K, Simon GM, Cravatt BF, Wong CH, 2007, “Tailored glycoproteomics and glycan site mapping using saccharide-selective bioorthogonal probes.”, Journal of the American Chemical Society, 129(23), 7266-7267. (SCIE)
  • Sawa M, Hsu TL, Itoh T, Sugiyama M, Hanson SR, Vogt PK, Wong CH, 2006, “Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo.”, Proceedings of the National Academy of Sciences of the United States of America, 103(33), 12371-12376. (SCIE)