鄭婷仁博士
姓名 鄭婷仁博士
現任 研究技師
所屬單位
高速篩選核心實驗室、酵素及細胞活性分析平台建立、小分子生物活性評估、高速篩選自動化實驗設計及執行

Ph.D., Life Sciences, National Tsing Hua University, Taiwan, 1999
B.Eng, Chemical Engineering, National Tsing Hua University, Taiwan, 1993
 
名片
專長

設施管理/專業知識:

  1. 管理高速篩選核心實驗室
    篩選核心實驗室提供高通量實驗(high-throughput screening)設計及執行的一站式服務。研究人員可提供RNAi/CRISPR/ Antibody/Enzyme variants library進行微量液體分注；在小分子篩選方面，我們設計了不同的小分子庫(含基本的FDA-approved drug collection)提供使用。另一方面，亦可提供多樣功能分析平台，協助研究人員使用自有分子庫進行生物活性分析，協助增加化合物的應用範圍並提升化合物的價值。本核心設施也將開放可單獨使用之儀器以及高速天然物分離純化服務以推廣相關儀器使用。

  2. 支援中心研究團隊對活性分析的需求；例如針對有興趣的藥物標的建立生化分析及活體內活性分析系統並執行藥物篩選。目前的協助範圍包含了:

    • 利用分生及生化技術發展藥物標的之生化活性偵測系統, 如酵素反應
    • 設計藥物標的之活體內活性偵測系統來決定化合物在活體內之活性
    • 應用分析系統進行高速藥物篩選選擇具活性之化合物
    • 評估及測試小分子及天然化合物的生物活性
    • 評估疫苗的效果
 

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經歷
  • 2012-present Senior research scientist, Genomics Research Center, Academia Sinica
  • 2008-2012 Associate Research scientist, Genomics Research Center, Academia Sinica
  • 2005-2008 Assistant Research scientist, Genomics Research Center, Academia Sinica
  • 2000-2005 Post-doctoral Research Associate, Keck Graduate Institute of Applied Life Science, USA
  • Tseng YW, Yang TJ, Hsu YL, Liu JH, Tseng YC, Hsu TW, Lu Y, Pan SH,* Cheng TR,* Fang JM*, 2024, “Dual-targeting compounds possessing enhanced anticancer activity via microtubule disruption and histone deacetylase inhibition.”, European journal of medicinal chemistry, 265, 116042. (SCIE)
  • Wang SC, Liao HY, Zhang JY, Cheng TR,* Wong CH*, 2019, “Development of a universal influenza vaccine using hemagglutinin stem protein produced from Pichia pastoris.”, Virology, 526, 125-137. (SCIE)
  • Wu WS, Cheng WC, Cheng TR,* Wong CH*, 2018, “Affinity-Based Screen for Inhibitors of Bacterial Transglycosylase.”, Journal of the American Chemical Society, 140, 2752-2755. (SCIE)
  • Huang LY, Wang SC, Cheng TR,* Wong CH*, 2017, “Undecaprenyl Phosphate Phosphatase Activity of Undecaprenol Kinase Regulates the Lipid Pool in Gram-Positive Bacteria.”, Biochemistry, 56(40), 5417-5427. (SCIE)
  • Huang LY, Huang SH, Chang YC, Cheng WC, Cheng TJ, Wong CH, 2014, “Enzymatic synthesis of lipid II and analogues.”, Angewandte Chemie-International Edition, 53, 8060-8065. (SCIE)
  • Huang SH, Wu WS, Huang LY, Huang WF, Fu WC, Chen PT, Fang JM, Cheng WC, Cheng TJ, Wong CH, 2013, “New continuous fluorometric assay for bacterial transglycosylase using forster resonance energy transfer.”, Journal of the American Chemical Society, 135(45), 17078-17089. (SCIE)
  • Liao HY, Hsu CH, Wang SC, Liang CH, Yen HY, Su CY, Chen CH, Jan JT, Ren CT, Chen CH, Cheng TJ, Wu CY, Wong CH, 2010, “Differential receptor binding affinities of influenza hemagglutinins on glycan arrays.”, Journal of the American Chemical Society, 132(42), 14849-14856. (SCIE)
  • Cheng TJ, Wu YT, Yang ST, Lo KH, Chen SK, Chen YH, Huang WI, Yuan CH, Guo CW, Huang LY, Chen KT, Shih HW, Cheng YS, Cheng WC, Wong CH, 2010, “High-throughput identification of antibacterials against methicillin-resistant Staphylococcus aureus (MRSA) and the transglycosylase.”, Bioorganic & medicinal chemistry, 18(24), 8512-8529. (SCIE)
  • Su CY, Cheng TJ, Lin MI, Wang SY, Huang WI, Lin-Chu SY, Chen YH, Wu CY, Lai MM, Cheng WC, Wu YT, Tsai MD, Cheng YS, Wong CH, 2010, “High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity.”, Proceedings of the National Academy of Sciences of the United States of America, 107(45), 19151-19156. (SCIE)
  • Cheng TJ, Sung MT, Liao HY, Chang YF, Chen CW, Huang CY, Chou LY, Wu YD, Chen YH, Cheng YS, Wong CH, Ma C, Cheng WC, 2008, “Domain requirement of moenomycin binding to bifunctional transglycosylases and development of high-throughput discovery of antibiotics.”, Proceedings of the National Academy of Sciences of the United States of America, 105(2), 431-436. (SCIE)
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