李志浩博士
姓名 李志浩博士
現任 特聘研究員
所屬單位 中心主任

免疫代謝體學、代謝調適反應、脂肪組織與免疫細胞交互反應、葡萄糖與脂肪酸之代謝體學、代謝組學、代謝疾病、神經發炎反應

Ph.D., University of Minnesota,USA, 1999
B.S., Chemical Engineering, National Tsing-Hua University, Taiwan, 1989
名片
  •  clee2023@as.edu.tw
研究方向/領域

研究方向/領域

本實驗室主要研究興趣為了解生理及病理過程的生物代謝能量調控。藉由採用分子/細胞生物學、生物化學、單細胞RNA定序技術以及代謝體學的方法來研究肥胖與相關代謝疾病之小鼠模型。近期研究項目著重在代謝與免疫訊號之相關作用，主要項目如下：

  • 適應生理壓力的代謝機制。如：耐力運動、冷暴露和進食/禁食等壓力環境。
  • 生理與病理情況下脂肪組織中免疫細胞的動態變化。
  • 小膠質細胞誘導之神經發炎的粒線體能量學。
  • 以多組學方法（例如：單細胞/單核RNA定序、ATAC定序、ChIP定序、蛋白質體學與代謝體學）了解脂肪細胞生物學。
Dr
經歷
  • 2023-present Director, Genomics Research Center, Academia Sinica
  • 2023-present Distinguished Professor, Genomics Research Center, Academia Sinica
  • 2015-2023 Professor, Harvard School of Public Health
  • 2010-2015 Associate Professor, Harvard School of Public Health
  • 2004-2010 Assistant Professor, Harvard School of Public Health
  • 1999-2004 Postdoctoral fellow, Salk Institute
榮譽
  • 2012 Armen H. Tashjian Jr. Award for Excellence in Endocrine Research
  • 2011 The Mentoring Award by the HSPH graduating class of 2011
  • 2006 Scientist Development Grant awarded by the American Heart Association
  • 2005 The William F. Milton Fund Award
  • 1998 Bacaner Research Award, presented by Minnesota Medical Foundation for excellence in creative research
1. Immune-metabolic signaling crosstalk in tissue homeostasis
 
a. Kang K, Reilly SM, Karabacak V, Gangl MR, Fitzgerald K, Hatano B, Lee CH. Adipocyte-derived Th2 cytokines and myeloid PPAR delta regulate macrophage polarization and insulin sensitivity. Cell Metab. 2008; 7:485-495.  PMID: 18522830. PMCID: PMC2586840
b. Bhargava P, Li C, Stanya KJ, Jacobi D, Liu S, Dai L, Liu S, Gangl MR, Harn DA, Lee CH. Immunomodulatory glycan LNFPIII alleviates hepatosteatosis and insulin resistance through direct and indirect control of metabolic pathways. Nat Med. 2012; 18:1665-1672. PMID: 23104131. PMCID: PMC3493877
c. Stanya KJ, Jacobi D, Liu S, Bhargava P, Dai L, Gangl MR, Inouye K, Barlow JL, Ji Y, Mizgerd JP, Qi L, Shi H, McKenzie, Lee CH. Direct control of hepatic glucose production by Il-13. J Clin Invest 2013; 123:261-271. PMID: 23257358. PMCID: PMC3533296
d. Knudsen NH, Stanya KJ, Hyde AL, Chalom MM, Alexander RK, Liou YH, Gangl MR, Jacobi D, Liu S, Sopariwala DH, Fonseca-Pereira D, Li J, Hu FB, Garrett WS, Narkar V, Ortlund EA, Kim JH, Paton CM, Cooper JA, Lee CH. Interleukin 13 drives metabolic conditioning of muscle to endurance exercise. Science 2020; 368: eaat3987. PMID: 32355002.
 
2. Energy metabolism and mitochondrial function in the liver-muscle axis
 
a. Liu S, Brown JD, Stanya KJ, Homan E, Leidl M, Inouye K, Bhargava P, Gangl MR, Dai L, Hatano B, Hotamisligil GS, Saghatelian A, Plutzky J, Lee CH. A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid utilization. Nature 2013; 502:550-553. PMID: 24153306. PMCID: PMC4141623
b. Jacobi D, Liu S, Burkewitz K, Kory N, Knudsen NH, Alexander RK, Unluturk U, Li X, Kong X, Hyde AL, Gangl MR, Mair WB, Lee CH. Hepatic Bmal1 regulates rhythmic mitochondrial dynamics and promotes metabolic fitness. Cell Metab 2015; 22:709-720. PMID: 26365180; PMCID: PMC4598294.
c. Liou YH, Personnaz J, Jacobi D, Knudsen NH, Chalom MM, Starost KA, Nnah IC, Lee CH. Hepatic Fis1 regulates mitochondrial integrated stress response and improves metabolic homeostasis. JCI Insight 2022; 7: e150041. PMID: 35015731.
 
3. Transcriptional regulation of metabolic and inflammatory processes
 
a. Reilly SM, Bhargava P, Liu S, Gangl MR, Gorgun C, Nofsinger RR, Evans RM, Qi L, Hu FB, Lee CH. Nuclear receptor co-repressor SMRT regulates mitochondrial oxidative metabolism and mediates aging related metabolic deterioration. 2010. Cell Metab, 2010; 12:643-653. PMID: 21109196. PMCID: PMC3033658
b. Dai L, Bhargava P, Stanya KJ, Alexander RK, Liou Y-H, Jacobi D, Knudsen NH, Hyde A, Gangl MR, Liu S, Lee CH. Macrophage alternative activation confers protection against lipotoxicity-induced cell death. Mol Metab 2017, 6:1186. PMID: 29031719. PMCID: PMC5641682.
c. Alexander RK, Liou YH, Knudsen NH, Starost KA, Xu C, Hyde AL, Liu SL, Jacobi D, Liao NS Lee CH. Bmal1 integrates mitochondrial metabolism and macrophage activation.  eLife 2020; 9: e54090. PMID: 32396064.
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