Hwai-I Yang, Ph.D.
Name Hwai-I Yang, Ph.D.
Incumbent Associate Professor
所屬單位
Epidemiology, multi-omics, biomarker, risk prediction, hepatitis

Ph.D., Graduate Institute of Epidemiology, School of Public Health, National Taiwan University, Taipei, Taiwan, 2006
Postdoctoral Fellow, Genomics Research Center, Academia Sinica, Taipei, Taiwan, 2006- 2011
NCLscan:
研究方向/領域

RESEARCH INTERESTS

Our major research interests:

  1. Epidemiology of viral hepatitis
    Conducting longitudinal studies to delineate the incidence and determinants (including viral, host, and environmental factors) of milestone transitions and disease progression in the natural history of chronic hepatitis B and C.
    Recently, the focus has been on employing full-length deep sequencing of the hepatitis B virus to comprehend the distribution of quasispecies and variants in chronic hepatitis B patients. Investigations are underway to understand how these viral quasispecies interact with human genetic and immune factors, influencing the progression of the disease.
     
  2. Development of risk prediction scores: Deriving and validating risk prediction tools which integrate multiple clinical and multi-omic parameters to predict the progression and adverse sequelae of chronic hepatitis B and C.
     
  3. Health outcomes and high-risk groups for people with fatty liver and metabolic disorders.
     
  4. Biomarkers for early cancer detection: Exploring multi-omics pre-diagnostic biosignatures with potential for predicting major cancers.

 
EDUCATION AND POSITIONS HELD
  • 2024-present Director, Taiwan Biobank, Academia Sinica, Taiwan
  • 2019-2023 Deputy Director, Genomics Research Center, Academia Sinica, Taiwan
  • 2014-present Adjunct Associate Professor, Graduate Institute of Clinical Medicine, National Yang-Ming University, Taiwan
  • 2012-present Associate Professor, Genomics Research Center, Academia Sinica, Taiwan
  • 2011-2013 Associate Professor, Graduate Institute of Clinical Medicine, China Medical University, Taiwan
HONORS
  • 2013 The 2013 Award for Outstanding Contributions in Science and Technology, Executive Yuan, Taiwan
  • 2013 Ta-You Wu Memorial Award, National Science Council, Taiwan
  • 2010 The 20th Wang Ming-Ning Award, Taiwan
  • 2007-2008 Distinguished Postdoctoral Scholar of Academia Sinica, Taiwan
  • 2006 Honorary Member, Phi Tau Phi Scholastic Honor Society, Taiwan
  • 2004 Prof. K-P Chen Award for the Best Public Health Paper, Taiwan Public Health Association, Taiwan
Year Paper Title
2025 Li TH, Huang YS, Ma CC, Tsai SY, Tsai HC, Yeh HY, Shen HC, Hong SY, Su CW, (Yang HI*, Yang YY*, Hou MC, GCKR Polymorphisms Increase the Risks of Low Bone Mineral Density in Young and Non-Obese Patients With MASLD and Hyperuricemia., KAOHSIUNG JOURNAL OF MEDICAL SCIENCES, 2025
2025 Huang YT, Hsu YC, (Yang HI, Lee MH, Lai TS, Chen CJ, Huang YT, Corrigendum: "Causal Mediation Analyses for the Natural Course of Hepatitis C: A Prospective Cohort Study" [J Epidemiol 35(1) (2025) 21-29]., JOURNAL OF EPIDEMIOLOGY, vol. doi: 10.2188/jea.JE20250177., Online ahead of print., 2025
2025 Tseng TC, Huang SC, Pan MH, Liu CJ, Chen CJ, Yang WT, Tsai CH, Su TH, Yang HC, Liu CH, Chen PJ, (Yang HI*, Kao JH*, Hepatitis B surface antigen level identifies patients with inactive chronic hepatitis B from Asia with HCC risk below surveillance threshold., GUT, 2025具代表性; 任職中研院著作;
2025 Tseng TC, Hosaka T, Pan MH, Liu CJ, Suzuki F, Chen CJ, Su TH, Kumada H, Yang WT, Yang HC, Liu CH, Chen PJ, (Yang HI*, Kao JH*, Higher level of Hepatitis B Surface antigen associated with delayed development of hepatocellular carcinoma in immune-tolerant patients., HEPATOLOGY, vol. doi: 10.1097/HEP.0000000000001313, Online ahead of prin, 2025具代表性; 任職中研院著作;
2025 Zhang T, Huang CJ, Chen HT, Huang YH, Pan MH, Lee MH, Viard M, Hildesheim A, Pfeiffer RM, Carrington M, Chen CJ, Zhu B, Lenz TL, Jiang D*, (Yang HI*, Liu Z, HLA-DQB1*03:01 and risk of Hepatitis B virus-related hepatocellular carcinoma., HEPATOLOGY, vol. doi: 10.1097/HEP.0000000000001307, Online ahead of print, 2025任職中研院著作;
2025 Chen CL, Yang WS, (Yang HI, Chen CF, Wang LY, Lu SN, Kao JH, Chen PJ, Chen CJ, Plasma Adiponectin Levels in Relation to Chronic Hepatitis B Infection Progression to Liver Cancer Milestones: A Prospective Study., LIVER CANCER, vol. 14(1), 19-35, 2025任職中研院著作;